Plant Transcription Factor Database
Previous version: v3.0
Aethionema arabicum
M-type_MADS Family
Species TF ID Description
AA10G00033M-type_MADS family protein
AA10G00034M-type_MADS family protein
AA10G00035M-type_MADS family protein
AA10G00036M-type_MADS family protein
AA18G00023M-type_MADS family protein
AA18G00024M-type_MADS family protein
AA18G00100M-type_MADS family protein
AA1G00065M-type_MADS family protein
AA24G00041M-type_MADS family protein
AA26G00639M-type_MADS family protein
AA26G00657M-type_MADS family protein
AA26G00658M-type_MADS family protein
AA30G00166M-type_MADS family protein
AA30G00167M-type_MADS family protein
AA30G00169M-type_MADS family protein
AA30G00250M-type_MADS family protein
AA31G00028M-type_MADS family protein
AA31G00178M-type_MADS family protein
AA31G00704M-type_MADS family protein
AA37G00186M-type_MADS family protein
AA39G00031M-type_MADS family protein
AA39G00166M-type_MADS family protein
AA39G00447M-type_MADS family protein
AA40G00157M-type_MADS family protein
AA40G00158M-type_MADS family protein
AA40G00159M-type_MADS family protein
AA46G00155M-type_MADS family protein
AA482G00004M-type_MADS family protein
AA4G00042M-type_MADS family protein
AA4G00073M-type_MADS family protein
AA4G00238M-type_MADS family protein
AA53G00738M-type_MADS family protein
AA61G00470M-type_MADS family protein
AA72G00006M-type_MADS family protein
AA76G00002M-type_MADS family protein
AA8G00332M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513